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GSTP1 and GSTO1 single nucleotide polymorphisms and the response of bladder cancer patients to intravesical chemotherapy.
Deng X, Yang X, Cheng Y, Liu X, Li X, Zhao R, Qin C, Lu Q, Yin C. Deng X, et al. Sci Rep. 2015 Sep 10;5:14000. doi: 10.1038/srep14000. Sci Rep. 2015. PMID: 26354850 Free PMC article.
Patients carrying the GSTP1 AG+GG and GSTO1 AC+AA genotypes had an unfavorable RFS. Patients with the GSTP1 AA and GSTO1 CC genotypes had a reduced risk of recurrence after the instillation of epirubicin. In addition, patients with the GSTP1 rs1695 AA genotype had a …
Patients carrying the GSTP1 AG+GG and GSTO1 AC+AA genotypes had an unfavorable RFS. Patients with the GSTP1 AA and GSTO1 CC ge …
A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma.
Wang YH, Yeh SD, Shen KH, Shen CH, Juang GD, Hsu LI, Chiou HY, Chen CJ. Wang YH, et al. Toxicol Appl Pharmacol. 2009 Nov 15;241(1):111-8. doi: 10.1016/j.taap.2009.08.008. Epub 2009 Aug 15. Toxicol Appl Pharmacol. 2009. PMID: 19686770
A significantly increased UC risk of 3.9 was observed in study subjects with H2-H2 diplotype of GSTO1 and GSTO2. The significantly highest UC risk of 9.0 was found for those with all environmental risk factors of cigarette smoking, alcohol consumption, arsenic and occupati …
A significantly increased UC risk of 3.9 was observed in study subjects with H2-H2 diplotype of GSTO1 and GSTO2. The significantly hi …
GSTO1*C/GSTO2*G haplotype is associated with risk of transitional cell carcinoma of urinary bladder.
Djukic T, Simic T, Radic T, Matic M, Pljesa-Ercegovac M, Suvakov S, Coric V, Pekmezovic T, Novakovic I, Dragicevic D, Savic-Radojevic A. Djukic T, et al. Int Urol Nephrol. 2015 Apr;47(4):625-30. doi: 10.1007/s11255-015-0933-0. Epub 2015 Feb 26. Int Urol Nephrol. 2015. PMID: 25716313
The study subjects with GSTO1*C/GSTO2*G (GSTO1 wild-type/GSTO2 mutant) haplotype were at the highest risk of the development of transitional cell carcinoma of urinary bladder (OR 2.8, 95% CI 1.5-5.2, p = 0.002). CONCLUSIONS: Our results indicate that GSTO1*C/ …
The study subjects with GSTO1*C/GSTO2*G (GSTO1 wild-type/GSTO2 mutant) haplotype were at the highest risk of the development o …
Polymorphisms in drug-metabolizing genes and urinary bladder cancer susceptibility and prognosis: Possible impacts and future management.
Silva IMD, Vacario BGL, Okuyama NCM, Barcelos GRM, Fuganti PE, Guembarovski RL, Cólus IMS, Serpeloni JM. Silva IMD, et al. Gene. 2024 May 20;907:148252. doi: 10.1016/j.gene.2024.148252. Epub 2024 Feb 11. Gene. 2024. PMID: 38350514 Review.
The most studied candidate genes/loci of phase I metabolism were CYP1B1, CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2A6, CYP3E1, and ALDH2, and those in phase II were GSTM1, GSTT1, NAT2, GSTP1, GSTA1, GSTO1, and UGT1A1. We used the 46 genes to construct a network of proteins and t …
The most studied candidate genes/loci of phase I metabolism were CYP1B1, CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2A6, CYP3E1, and ALDH2, and thos …
Downregulation of glutathione S-transferase M1 protein in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced mouse bladder carcinogenesis.
Chuang JJ, Dai YC, Lin YL, Chen YY, Lin WH, Chan HL, Liu YW. Chuang JJ, et al. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):322-330. doi: 10.1016/j.taap.2014.06.018. Epub 2014 Jul 3. Toxicol Appl Pharmacol. 2014. PMID: 24998975
In contrast, the sequentially upregulated proteins identified were GSTO1, keratin 15 and myosin light polypeptide 6. Western blotting confirmed that GSTM1 and NQO-1 were decreased, while GSTO1 and Sp1 were increased, after BBN treatment. ...
In contrast, the sequentially upregulated proteins identified were GSTO1, keratin 15 and myosin light polypeptide 6. Western blotting …
Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients.
Djukic TI, Savic-Radojevic AR, Pekmezovic TD, Matic MG, Pljesa-Ercegovac MS, Coric VM, Radic TM, Suvakov SR, Krivic BN, Dragicevic DP, Simic TP. Djukic TI, et al. PLoS One. 2013 Sep 11;8(9):e74724. doi: 10.1371/journal.pone.0074724. eCollection 2013. PLoS One. 2013. PMID: 24040330 Free PMC article.
OBJECTIVE: To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on …
OBJECTIVE: To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GST …